Just to clarify, you are seeing e-mails that are spoofing your domain? If so, Antigen does not have a way to combat spoofing of your internal addresses, unfortunately.
That is correct, that is my challenge. I have users complaining about receiving mail from theirselves with viagra ads. So, to confirm there is nothing I can do about this?
If you are using Exchange 2003, I know there are some things you can do there to combat spoofing. But unfortunately, it can't be done in Antigen. If you were to try to block your domain name in Antigen, of course you would be blocking the legitimate mail also.
You may want to double-check with Exchange, but I believe there is a Recipient Filtering and an option called "Filter recipients who are not in the Directory".
I would add an SPF record to your zone file. That should stop this issue. Adding the record will eliminate the issue of spam looking like it was sent from your domain name to both internal and external issues.