I wasn't sure if this was the right forum for 4.6 stuff but I wanted to let you know that
Nidhi Doshi (App-V 4.6 Sequencer Program Manager) recently posted on some of the major changes to the Sequencer user interface in our 4.6 release which vastly improves the sequencing experience.
You can read all of the details here:
http://blogs.technet.com/softgrid/archive/2009/08/25/sequencer-ui-changes-in-app-v-4-6.aspxJ.C. Hornbeck | Microsoft