o3-301.htm" contains the following virus: "VIRUS= Trojan.JS.Agent.aaf (Kaspersky5); Tagged ID: 166CB8E0_1D31_42D2_9E69_630EF6007781".
If you want to open this file, you'll need to clean the file using your own virus scanning software. Do you want to save the file to your computer and attempt to clean it?"
So, I basically need to exclude the particular directory that hosts these files and am not able to see how I can do this in Forefront?
I don't believe there s any way to exclude a particular directory from realtime scanning within Forefront for Sharepoint. If you know that this file is not a virus, then this would be a false positive detection, probably by just the Kaspersky engine, and as such I would recommend that you submit a sample of this file to Microsoft who will work together with Kaspersky to alter their definition files to allow through this particular file. More details on how to do this can be found at:-