When I create a network share is it possible to only use share permissions?
No, it is not. The share permissions act as a filter to the file (aka NTFS) permissions.
If you format the volume as NTFS, you have to grant some account read or read+write access. There is no point in having a volume with no permissions set, no one could access it.
Lets say that you have an E:\ drive and the permissions are set to "everyone full control". Then you share out the E:\ drive as "Data" with the share permissions set to "everyone read". Any user who can RDP to the server,
or any application running on the server, can do anything they want to with the E:\ drive. They are accessing it locally and not going through the share and they have full control.
But any user, including administrators, who access the files via the share, \\servername\Data, only have read access. It doesn't matter that the NTFS permissions have "everyone full control", since the files are being accessed
through the share, the share permissions are restricting access to read only.
That's the same answer that Seth provided, just a little more verbose to try to explain how it works.