Hi TianChen,
Yes, you can use a wildcard cert in a Hybrid environment.
Please refer to the following article to request a wildcard cert:
Create an Exchange 2016 certificate request for a certification authority
Moreover, when using a wildcard cert, you may run into an issue with Exchange Hybrid Migration Wizard, there is an workaround for your reference:
Wild Card Certificates and Hybrid Configuration Wizard
Hope this helps,
Best Regards,
Niko Cheng
TechNet Community Support
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