Posting this for information, but if anyone has any ideas for workarounds i'd be most grateful!
The Skype for Business 2015 Front End role will not run on computers with 4Kn hard disks.
When the FE service is started for the first time, it tries to start the Windows Fabric service. The Windows Fabric service attempts to configure itself on first fun, however the configuration fails and the service gets stuck in a loop constantly retrying
to set itself up.
The Skype for Business 2015 FE service therefore fails to start, due to the Windows Fabric service failing to start.
I've tested, and confirmed, the problem on SfB 2015 versions up to and including CU5 on Windows Server 2012 R2 and Windows Server 2016.
I have a PSS case open regarding this issue
The only known workaround is to move back to using 512 or 512e hard disks.
The Skype for Business 2015 Edge role works fine with 4Kn hard disks.