Hi,
All DPM 2007 post-sp1 hotfixes and all DPM 2010 hotfixes are cumulative - meaning you just need to install the latest fix and it will include all previous fixes.
So, yes, installing KB2250436 (2.0.8868.0) will include all previous fixes leading up to it.
Regards, Mike J. [MSFT] This posting is provided "AS IS" with no warranties, and confers no rights.