Hi Eos!
Does anyone else have the same issue?
Is the problem you describe the same as the screenshot below?

According to your description, I think this issue may related to Skype for Business client.
I did a test in my environment and I found when I make use of the EASE OF ACCESS—Display SETTINGS—Make TEXT Bigger feature and increase the text size to 125%, this issue will persist all the time. So we recommend you drag your slide to 100% to see if it
works. The Display settings are as follows:

Besides, we also recommend you try to change another PC see if this issue still persist.
Best Regards,
Jimmy Yang
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