Hi thatajguy,
Does the error occur to the particular user?
Is the user able to create files in the signature folder (%AppData%\Roaming\Microsoft\Signatures)?
Please check for and install all the available updates for both Windows 10 and Office 2013 to see if there will be any improvement.
If the issue persists, please try to
perform a clean boot in Windows, then have a try and see if issue persists. This helps eliminate whether the issue was caused by any software conflicts.
Any findings, please feel free to post back.
Regards,
Yuki Sun
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