Hi
You should configure subscription for Exchange 2013 edge servers to your Exchange servers.
You can subscribe an edge server in a site to multiple mailbox 2016 servers
You can import the Edge Subscription file and run EdgeSync on a standalone Exchange 2016 Mailbox server
Refer-
https://technet.microsoft.com/en-us/library/bb123800(v=exchg.160).aspx
https://technet.microsoft.com/en-us/library/dn635117(v=exchg.160).aspx
Make sure you open the below ports on the firewall
Inbound traffic:
SMTP – TCP port 25 (from Internet)
SMTP – TCP port 25 (from Edge server to Hub server on internal network)
Outbound traffic:
SMTP – TCP/UDP port 25 (from Edge to Internet)
SMTP – TCP/UDP port 25 (from Hub to Edge server)
Very IMP : Do not open the below mentioned ports on perimeter firewall. These ports should be open only on intranet firewall.
LDAP for Edge Sync – TCP port 50389 (from Mailbox to Edge server) Secure LDAP for Edge Sync – TCP port 50636 (from Mailbox to Edge server).
Remember to mark as helpful if you find my contribution useful or as an answer if it does answer your question.That will encourage me - and others - to take time out to help you Check out my latest blog posts on http://exchangequery.com Thanks Sathish
(MVP)