1. Disabled accounts do not authenticate.
2. For enabled users, as long as Windows authentication works (here it will because of the 2-way trust), ADFS will be able to authenticate (note that you can also make it work without a trust by creating an LDAP claim provider for the other forest, but then
you'll have no SSO).
3. I am not sure you bring these disabled accounts in the question. They seem to exist for Exchange. ADFS is agnostic of the Exchange configuration, it cares just about actual users authenticating.
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