Hi ExchangeGarrison,
According to the official document, Microsoft .NET Framework is usually installed when Windows Server 2012 R2 or Windows Server 2016 are installed. Skype for Business Server works with the following Microsoft .NET Framework versions:
• .NET 3.5
• .NET 4.5
• .NET 4.6.x
• .NET 4.7.1 and higher (for Skype for Business Server CU 5 or later releases)
You could refer to
Server requirements for Skype for Business Server 2015.
According to your description, if you want to install .NET 4.7.2, please install SFB Server CU5 or later release.
Best Regards,
Evan Jiang
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