Hi
stephen3610,
According to your description, I suggest that we could use the steps below to check.
https://support.microsoft.com/en-us/help/10164/fix-windows-update-errors
Few reasons could cause the error 643, we could try to reset the Windows Update Components and run the System Update Readiness tool to check. Please check
the link below about you can't install updates on a Windows-based computer to follow the steps.
https://support.microsoft.com/en-ca/help/2509997
If the issue still insists, it could be related to the Microsoft .NET Framework. You could manually uninstall and reinstall it.
Hope it will be helpful to you
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