Hello,
To backup the data on the computer in Vista business/Ultimate OS, I suggest you using the Windows built-in Backup and Restore Center. For more information, read the webpage below.
Explore the features: Windows Backup and Restore Center
http://www.microsoft.com/windows/windows-vista/features/backup.aspx
As to the concerns related to Windows Live OneCare, you might refer to the following KB article.
Supported backup devices for Windows Live OneCare
http://support.microsoft.com/kb/943913/en-us
Backup support in Windows Live OneCare
http://support.microsoft.com/kb/913736/en-us
Good Luck!
Andy