1. If you want to reduce the number of programs that start up when you switch on the computer, download and install the free Quick Startup (32-bit only, not 64-bit, although I’ve used it on 64-bit). Click on (highlight) an entry, then in the left pane choose Disable, Delete. If you are unsure about an entry and want to know more about it before disabling or deleting it, highlight it and then click More information at the bottom.
2. If you want to add a program, there is an Add option but, preferably, put it in one of the Startup folders not a Run key (in the registry).
Quick Startup, here http://www.glarysoft.com/qs.html?tag=download