Hello there..
We have a problem with an application that gets mails outside from the domain... it SOMETIMES shows the error "Mailbox Unavailable. The server response was: 5.7.54 SMTP; Unable to relay recipient in non-accepted domain".
I checked the recieve connector configuration on all the servers and it looks the same on all of them.
on the security tab:
checked TLS, Externally secured
Exchange servers, Anonymous users.
used to work fine and suddenly making problems